MAXIMIZING YOUR GENETIC POTENTIAL - Some guys walk by a gym and their muscles grow, for others it takes hard consistent work to make small gains. Most of this has to do with genetics. Now we can't alter your genetics but we can support them in a way that maximizes their potential.
Natural-T is designed to support key biological targets involved in producing testosterone, estrogen, stimulating protein synthesis, and triggering muscle fiber growth and replication:*
Testosterone Production
a.Luteinizing Hormone - Via natural pituitary stimulation and support*
b.Leydig Cells - Via natural stimulation and support*
Free Testosterone
a.Sex Hormone Binding Globulin - Via natural inhibition of this element*
Estrogen Management
a.Aromatase - Via naturally inhibiting this enzyme*
Anabolic Stimulation and Protein Synthesis*
a.Via naturally supporting muscle growth genes (PI3K/Akt pathway)*
Nutrient Absorption
a.Via glucuronidation inhibition and paralleled alteration on both the protein and mRNA expression levels of the nutrient transporter genes.
THE NATURAL-T TEAM
•Proprietary Ursolic Acid Anabolic Blend (U.A.A.B)
Is comprised of a patent-pending anti-catabolic lean mass potentiating element.* A proprietary extract from the Eriobotrya japonica, better known as the loquat, U.A.A.B. contains several beneficial compounds called triterpenoids. In a recent human clinical trial, U.A.A.B. was suggested to decrease the excretion of 3-methylhistidine (3-MH), which researchers use as an indicator of muscle protein breakdown.* Additionally, researchers from the University of Iowa performed an animal study and found evidence that ursolic acid can be anti-catabolic and anabolic.* They surmised that ursolic acid supported muscle gain and fat loss.* 1
Objectives:
•Support and Promote Anabolic Activity*
•Promote Fat Loss*
•Brassinosteroids
Are plant-derived hormones that are found at low levels in pollen, seeds, leaves, and young vegetative tissues throughout the plant kingdom. A recent set of animal studies has suggested that homobrassinolide, a powerful brassinosteroid found in the mustard plant, exhibits anabolic activity in skeletal muscle cells.* 2 These findings suggest that oral application of homobrassinolide may trigger selective anabolic response with minimal or no androgenic side effects.*3
Objectives:
•Support and Promote Anabolic Activity*
•Support Muscle Growth (number and size of muscle fibers)*
•Support Muscle Repair*
•Promote Overall Physical Performance*
•Safed Musli (Chlorophytum borivilianum)
Is an herb with spear shaped leaves found in the tropical wet forests in peninsular India. Studies suggest that the administration of Safed Musli may have an anabolic effect in treated animals as evidenced by weight gains in the body and reproductive organs and histological studies.* 4 Additional animal studies suggested that Safed Musli promotes sexual health and vigor. *5, 6, 7
Objectives:
•Support and Promote Anabolic Activity*
•Promote Sexual Health*
•Basella alba
Is a perennial vine found in the tropics. In two different animal studies it was suggested that Basella alba extracts enhanced testosterone production in Leydig cells in a concentration-dependent manner.* 8, 9 Leydig cells, located within the testes, produce testosterone in the presence of luteinizing hormone (LH).
Objectives:
•Support Total Testosterone Production*
•White button mushroom (Agaricus bisporus)
Were studied by researchers at the Beckman Research Institute. Study results suggested that white button mushroom phytochemicals help inhibit aromatase activity.* 10 This is important because estrogen is made from testosterone via conversion using the enzyme aromatase. Natural-T's goal is to help reduce aromatase activity, thereby reducing estrogen levels*.
Objectives:
•Support Healthy Estrogen Levels*
•Fenugreek
Also known as Trigonella foenum-graecum is a plant in the Fabaceae (bean) family. A recent human study published in the International Journal of Sport Nutrition and Exercise Metabolism, indicates that college men supplemented with Trigonella foenum-graecum for 8 weeks had significant increase in total and bioavailable testosterone levels, as well as a decrease in body fat, when in conjunction with a resistance-training program.* 11 A recent animal study indicates that furostanol glycosides isolated from Fenugreek appear to impart anabolic activity in male rats, without increasing total testosterone.* It is theorized that the mechanism for this action may be due to increased availability of testosterone by dissociating it from the stored form, i.e. sexual hormone binding globulin (SHBG). 12
Additional animal research has suggested that Fenugreek may support healthy growth hormone levels already within normal limits.* 13 A recent study was conducted with 47 resistance trained men to determine what effect, if any, the fenugreek extract had on training responses when coupled with creatine supplementation over an eight week period in comparison to the traditional dextrose plus creatine combinations that had been previously suggested to significantly increase adaptations stemming from resistance training. The results indicated that creatine plus fenugreek extract supplementation had the same impact on upper body strength and body composition as the combination of creatine with dextrose. Thus, the use of fenugreek with creatine supplementation may be an effective way to support creatine uptake while eliminating the need for excessive amounts of simple carbohydrates.* 14
Objectives:
•Support Total Testosterone Production*
•Support Free Testosterone Production*
•Promote Healthy Body Composition*
•Support Growth Hormone Levels already within normal levels*
•Tribulus alatus
Is a plant relative of the Tribulus terrestris that grows in the Middle East. It is suggested based in a recent animal study that Tribulus alatus extract may naturally promote free serum testosterone.* The study further concluded that Tribulus alatus extract appears to possess androgen-supporting properties.* 15 It is theorized that the steroidal saponins16 in Tribulus alatus might contribute to increasing endogenous testosterone levels by raising the level of luteinizing hormones (LH).* 16
Objectives:
•Support Total Testosterone Production*
•Support Free Testosterone Production*
•Promote Sexual Health*
•Bioperine®
Bioperine® Is a standardized extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper). Bioperine is used to help other nutrients become better absorbed into the blood stream. Bioperine works by inhibiting glucuronidation, which is a process that the body uses to make substances more water-soluble. More water-soluble substances are easier to be eliminated from the body through urination. When this process is inhibited the bioavailability of some substances is increased. BioPerine® is the only product sourced out of piperine to obtain a patented status for its ability to support the bioavailability of nutritional compounds. It is also the only source from piperine to have undergone clinical studies in the U.S. to substantiate its safety and efficacy for nutritional use.
Objectives:
•Improve Absorption of Ingredients*
•Astravar™
Is an all-natural plant-derived compound that is extracted from highly fractionated Panax notoginseng and Astragalus membranaceus. Research suggests that Astravar may improve the absorption of various nutrients at the cellular level. When a greater amount of these nutrients are transported from the blood stream into cells, rather than just floating in the blood stream, you have truly improved bioavailability. 17 Astravar also contains several ginsenosides. Ginsenosides belong to a group of compounds known as steroidal saponins, which are steroid molecules with attached sugar residues. In an animal study one of these ginsenosides known as rb1 was suggested to promote testosterone production indirectly through the stimulation of the luteinizing hormone.* 18 Further research also suggests that the ingredients in Astravar can increase eNOS (endothelial nitric oxide synthase), the enzyme that prompts nitric oxide production in endothelial cells.* 19
Objectives:
•Improve Absorption of Ingredients*
•Support Total Testosterone Production*
•Support Nitric oxide*
NATURAL-T FREQUENTLY ASKED QUESTIONS:
Q. Other than testosterone what does Natural-T™ target?
A. As we know testosterone is both androgenic and anabolic. The androgenic component of testosterone simply put, helps with our overall sense of well being, sexual health, strength, and muscle mass. The anabolic aspect of testosterone helps with protein synthesis and cell growth. Our objective with Natural-T is to support the body's own testosterone production, and stimulate protein synthesis via different biological mechanisms that do not have androgenic side effects. We believe this is the best natural option for muscle growth and strength.* Additionally we have included an estrogen management component as well which in our opinion is a must for any testosterone boosting supplement.*
Q. Do I need to cycle this product or can I take it all the time?
A. Although Natural-T is stimulating your body to produce its own testosterone, we recommend taking the product for 3 months maximum and then taking 4 weeks off.
Q. Why did you combine an estrogen management component to Natural-T™?
A. In men, estrogen is a byproduct of testosterone. Testosterone is
converted to estrogen via the enzyme aromatase. Estrogen is a very
needed hormone, but excess estrogen can be an issue. Our goal is
to create a healthy balance between testosterone and estrogen.
Q. How long will it take before I can "feel" Natural-T™
and what should I feel?
A. Everyone is different, some may feel the product in one
day, for others it may take a couple of weeks. As for what
you should feel, our goal is to have you feeling great by supporting
more energy, stamina, and strength.* Additionally, we
want to put you in an environment where you can promote
muscle growth and fat loss, and finally, you may feel a
bit more sexually charged.*
(1) Kunkel, S.D., et al. "mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass." Cell Metabolism 13 (2011): 627-38
(2) "Akt-Dependent Anabolic Activity of Natural and Synthetic Brassinosteroids in Rat Skeletal Muscle Cells." J Med Chem. 54.12 (2011): 4057-66. Epub 2011 May 26.
(3) "Anabolic Effect of Plant Brassinosteroid." FASEB J. 25.10 (2011): 3708-19. Epub 2011 Jul 11.
(4) "A Peer Reviewed of General Literature on Chlorophytum borivilianum Commercial Medicinal Plant." Int. J. Drug Dev. & Res. 3.1 (2011): 140-155.
(5) "Effects of Chlorophytum borivilianum on Male Rats." Phytother. Res. 22 (2008): 796–801.
(6) "Improvement of Penile Erection, Sperm Count and Seminal Fructose Levels in vivo and Nitric Oxide Release in vitro by Ayurvedic Herbs." Andrologia. 43.4 (2011): 273-7. doi: 10.1111/j.1439-0272.2010.01068.x. Epub 2011 Mar 28.
(7) "A Comparative Study on Activity of Some Ayurvedic Herbs in Male Albino Rats." Arch Sex Behav 38 (2009): 1009–1015.
(8) "Effects of Basella alba and Hibiscus macranthus Extracts on Testosterone Production of Adult Rat and Bull Leydig Cells." Asian J Androl. 7.4 (2005): 411-7.
(9) "Effects of the Methanol Extract of Basella alba L (Basellaceae) on Steroid Production in Leydig Cells." Int. J. Mol. Sci.12 (2001): 376-384; doi:10.3390/ijms12010376
(10) "White Button Mushroom Phytochemicals Inhibit Aromatase Activity." J Nutr. 131.12 (2001): 3288-93.
(11) Effects of a purported aromatase and 5á-reductase inhibitor on hormone profiles in college-age men. Int J Sport Nutr Exerc Metab. 2010 Dec;20(6):457-65.
(12) "Effect of Furostanol Glycosides from Trigonella foenum-graecum on the Reproductive System of Male Albino Rats." Phytother Res. 24.10 (2010): 1482-8.
(13) "Rat Growth-Hormone Release Stimulators from Fenugreek Seeds." Chem Biodivers.5.9 (2008): 1753-61.
(14) "Effects of Combined Creatine Plus Fenugreek Extract vs. Creatine Plus Carbohydrate Supplementation on Resistance Training Adaptations." Journal of Sports Science and Medicine 10 (2011): 254-260.
(15) "Free Serum Testosterone Level in Male Rats Treated with Tribulus Alatus Extracts." Int Braz J Urol. 33.4 (2007): 554-8; discussion 558-9.
(16) "Steroidal Saponins from the Aerial Parts of Tribulus alatus Del." Phytochemistry. 67.10 (2006): 1011-8. Epub 2006 May 2.
(17) Tsuchung Chang, Wen-liang Chang, and m Shu-fun Huang. "A Clinically Validated Natural Ingredient that Transports Significantly Greater Amount of Nutrients in Blood Stream into Cells for Truly Improved Bioavailability." Nuliv Science.
(18) Stimulation of the secretion of luteinizing hormone by ginsenoside-Rb1 in male rats. Chin J Physiol. 2003 Mar 31;46(1):1-7.
(19) "Panax notoginseng and its Components via Stimulation of Endothelial-dependent Vessel Dilatation." Vascul Pharmacol. 2012 Jan 3. [Epub ahead of print]
